The defeat halted Brighton's impressive three-game winning streak which included a 4-1 win over Chelsea and a 3-1 victory at Arsenal in the League Cup on Wednesday.
A round-up of Saturday's action in the Premier League.
Spain face Ronald Koeman's Netherlands away on Thursday before returning home for the second-leg on March 23.
Arsenal took a seven-point lead at the top of the Premier League after a scoreless draw with Nottingham Forest on Saturday.
Javier Hernandez went off clutching the match ball after helping leaders Manchester United fight back for a 3-2 win at Aston Villa after Arsenal were held in another rip-roaring Saturday of Premier League action.
Smart goalkeeping by Thomas Sorensen enabled Aston Villa hold Wigan Athletic 0-0 in the English Premier League.
Aston Villa striker Christian Benteke scored a hat-trick to lead his side to a crushing 6-1 win over Sunderland on Monday that gave them a massive lift in their battle for Premier League survival.
Chelsea, playing with a swagger missing for much of the season, routed Aston Villa 8-0 on Sunday.
Chelsea marked the start of Dutch coach Guus Hiddink's spell in charge with a 1-0 victory against Aston Villa in Birmingham on Saturday to keep their Premier League hopes alive. Hiddink, who has taken the job until the end of the season following the sacking of Luiz Felipe Scolari, watched the top flight's leading scorer Nicolas Anelka bag a vital three points with a well-worked goal before halftime.
Fernando Torres struck in stoppage time to give Liverpool a desperately needed 1-0 win at Aston Villa in the Premier League on Tuesday.
A last-gasp Christian Benteke penalty handed Tim Sherwood his first win as Aston Villa manager.
Manchester United's exiled forward Marcus Rashford has delivered a scathing assessment of the Premier League side's struggles
A summary of Saturday's action in the Premier League.
Arsenal's title hopes hit with 2-0 loss to Villa as Man City get boost
Aston Villa took full advantage of the absence of the other Premier League high-fliers on Saturday, winning 1-0 at West Ham United to climb to third. A deflected James Milner shot 12 minutes from time gave Villa 34 points from 18 games and pushed them above Manchester United (32).
Irish striker Robbie Keane scored the winner as Tottenham Hotspur recovered from a goal down with 12 minutes left to beat Aston Villa 2-1.
Obafemi Martins scored twice as Newcastle United produced a stirring second-half performance to beat Aston Villa 2-0 on Monday to move off the bottom of the Premier League.
Liverpool ensured it was an unhappy return for former manager Gerard Houllier with a comfortable 3-0 Premier League win over Aston Villa at Anfield on Monday.
Aston Villa kept alive their slim hopes of Champions League qualification with an easy 2-0 Premier League win at relegation-threatened Hull City on Wednesday.
Manchester City's Matheus Nunes scored deep in injury time to salvage a crucial 2-1 Premier League victory over Aston Villa on Tuesday in their breathless chase for a Champions League berth next season.
Neville said that within next week or two, Manchester United will have to "magic up a bit more money" or bring someone on loan.
Javier Hernandez went off clutching the match ball after helping leaders Manchester United fight back for a 3-2 win at Aston Villa after Arsenal were held in another rip-roaring Saturday of Premier League action.
The post was deleted about an hour later. The league did not immediately respond to a request for comment.
Scott McTominay's header proved decisive for Manchester United
Aston Villa and Ireland goalkeeper Shay Given will be out of action for a month after suffering a torn hamstring, the Premier League club said on their website (www.avfc.co.uk) on Monday.
Aston Villa kept Tottenham Hotspur bottom of the Premier League on Monday with a deserved 2-1 victory at White Hart Lane. Villa scored after five minutes through Nigel Reo-Coker and again early in the second half when Ashley Young's shot squirmed under Tottenham's Brazilian goalkeeper Heurelho Gomes.
Aston Villa took a step towards next month's League Cup final at Wembley when a James Milner goal gave them a 1-0 win over Blackburn Rovers in the first leg of a lively semi-final at Ewood Park on Thursday.
A preview of Saturday's matches in the English Premier League.
England midfielder Jack Grealish joined Everton on a season-long loan from Manchester City on Tuesday as he seeks to restart his stalled international career.
Manchester United closed in on the Premier League's pole position after a 2-1 home win over Aston Villa on Friday put them level on points and games played with champions and leaders Liverpool.
City midfielder Phil Foden was not named in England coach Thomas Tuchel's squad for a pair of upcoming games, after requesting to be omitted. Foden said this week he was nursing an ankle injury.
Manchester United fought back to beat Aston Villa 3-2 in the Premier League at Old Trafford on Sunday with an injury time winner from 17-year-old substitute Federico Macheda. United lead the table with 68 points from 30 matches, one point more than Liverpool who had gone top on Saturday after their 1-0 stoppage time win at Fulham.
Liverpool fielded a starting lineup consisting mainly of reserves and youth team players with an average age of 19.4, a club record.
A Kamil Zayatte own goal two minutes from time gave Aston Villa a 1-0 win at Hull City on Tuesday and lifted them to fourth place in the Premier League.
Big-spending Manchester City fought back to draw 1-1 at Aston Villa on Monday and move ahead of Arsenal and Liverpool into fourth place in the Premier League table.
Manchester City striker Erling Haaland is in contention to start against Southampton this weekend, manager Pep Guardiola said on Friday after the Norwegian striker recovered from an ankle injury that kept him sidelined for nearly six weeks.
Aston Villa blew a chance to go eight points clear of Arsenal in the race for England's fourth Champions League berth Sunday after conceding two late goals against relegation-threatened Stoke City. The 2-2 draw, with Stoke cancelling out their hosts' 2-0 lead in the final three minutes, left fourth-placed Villa six points ahead of Arsenal and three adrift of second-placed Chelsea and Liverpool in the Premier League.
Queens Park Rangers salvaged a 1-1 home draw against Aston Villa in the Premier League on Sunday with their first home goal of the season coming from Villa defender Richard Dunne who put through his own net in stoppage time.
Aston Villa's miserable season went from bad to worse when they slumped to a 2-1 defeat at second tier Millwall in the fourth round of the FA Cup on Friday.
Aston Villa moved into the thick of a four-way battle for fourth place in the Premier League with a 2-1 win at struggling Wigan Athletic on Tuesday.
